A 26-year-old woman is suspected to suffer from systemic lupus erythematosus due to systemic lesions of skin, vessels, joints, serous tunics, and heart that developed after photosensitization. The following is detected: LE cells, antibodies to native DNA, isolated anti-centromere antibodies, rheumatoid factor is 1:100, Wassermann reaction is positive, circulating immune complex is 120 units. What immunological indicators are considered to be specific to this disease?

Answer options

1. Rheumatoid factor
2. Increased circulating immune complex
3. Immunoglobulin A
4. DNA antibodies
5. Anti-centromere antibodies

Explanation

A 26-year-old woman is suspected to suffer from systemic lupus erythematosus due to systemic lesions of skin, vessels, joints, serous tunics, and heart that developed after photosensitization. The following is detected: LE cells, antibodies to native DNA, isolated anti-centromere antibodies, rheumatoid factor is 1:100, Wassermann reaction is positive, the circulating immune complex is 120 units. What immunological indicators are considered to be specific to this disease?Immunoglobulin A → Mucous membrane immune function DNA antibodies → Or ANA (antinuclear antibody) Or ds-DNA antibodies Rheumatoid factor → Rheumatoid Arthritis Anti-centromere antibodies → in systemic scleroderma (formerly called CREST syndrome), and occasionally in the diffuse form of scleroderma.