A patient suffering from infiltrative pulmonary tuberculosis was prescribed streptomycin, rifampicin, isoniazid, pyrazinamide, vitamin C. One month after the beginning of the treatment the patient started complaining of reduced hearing and tinnitus. What drug has such a side effect?

Answer options

1. Streptomycin
2. Rifampicin
3. Pyrazinamide
4. Isoniazid
5. Vitamin C

Explanation

A patient suffering from infiltrative pulmonary tuberculosis was prescribed streptomycin, rifampicin, isoniazid, pyrazinamide, vitamin C. One month after the beginning of the treatment the patient started complaining of reduced hearing and tinnitus. What drug has such a side effect?A. Since streptomycin belongs to the group of aminoglycosides, which is characterized by a violation of the VIII pair of cranial nerves, i.e. ototoxicity, this drug caused the described adverse reactions. B. The main side effects of isoniazid include peripheral polyneuropathy (due to competitive inhibition of vitamin B6) and hepatotoxicity. Ototoxicity and hearing impairment do not relate to the side effects of isoniazid. C. Rifampicin is characterized by hepatotoxicity, nephrotoxicity, and staining of biological fluids in red. Ototoxicity does not apply to the side effects of rifampicin D. The main side effects of pyrazinamide are hepatotoxicity, allergic reactions, gastrointestinal disorders, hyperuricemia. Ototoxicity does not belong to the main side effects of pyrazinamide E. Vitamin C has no side effects and contraindications except cases of individual intolerance. Ototoxicity also does not apply to the side effects of vitamin C. Such adverse reaction of antituberculosis drugs as ototoxicity was provoked by streptomycin.