A 15-year-old patient presents with delayed physical development and periodically develops icteric skin. Spleen is 16x12x10 cm, cholecystolithiasis is observed in the patient, there is a skin ulcer on the left calf in its lower third. The blood has: erythrocytes – 3.0 · 1012/L, Hb – 90 g/L, color index – 1.0, microspherocytosis, reticulocytosis. Total serum bilirubin – 56 mcmol/L, indirect bilirubin – 38 mcmol/L. What treatment method is optimal in this case?