A 15-year-old patient presents with delayed physical development and periodically develops icteric skin. Objectively, the spleen is 16x12x10 cm, cholecystolithiasis is observed in the patient, there is a skin ulcer on the left calf in its lower third. In the blood: erythrocytes — 3.0 • 1012 /L, Hb — 90 g/L, color index — 1.0, microspherocytosis, reticulocytosis. Total serum bilirubin — 56 mcmol/L, indirect bilirubin — 38 mcmol/L. What treatment method would be optimal in this case?