A 40-year-old woman suffering from diffuse toxic goiter presents with constant increase of her body temperature. What mechanism results in such clinical presentation?

Answer options

1. Increased breakdown of glycogen in hepatic cells
2. Separation of oxidation and phosphorization in cell mitochondria
3. Increased catabolism of protein in cells
4. Increased excitability of nerve cells
5. Increased cell sensitivity to catecholamines