A patient complains of toothache. On examination he has been diagnosed with pulpitis. Which factor played the main pathogenic role in the development of pain syndrome in this case?

Answer options

1. Activation of one of the complement system components
2. Vasospasm
3. Increased intratissular pressure in the dental pulp
4. Inadequate stimulation of the mandibular nerve branch
5. Interleukin action