A culture of monkey cells (Vero) and a group of mouse sucklings were infected with an inoculum taken from a child with provisional diagnosis "enterovirus infection". There was no cytopathic effect on the cell culture but mouse sucklings died. What enteric viruses might have caused disease of this child?

Answer options

1. Polioviruses
2. Coxsackie A
3. Unclassified enteric viruses 68-71
4. ECHO virus
5. Coxsackie B

Explanation

Coxsackie A virus (CAV) is a cytolytic Coxsackievirus of the Picornaviridae family, and enterovirus (a group containing the polioviruses, coxsackieviruses, and echoviruses). Coxsackieviruses type are based on their pathogenicity in newborn mice (mouse suckling's). Group A causes flaccid paralysis while group B causes spastic paralysis. Coxsackie A virus causes paralysis and death of the mice; Coxsackie B causes less severe infection in the mice.