In a 35-year-old woman diabetes mellitus was complicated by development and progression of cataract that is likely to be caused by:

Answer options

1. Cellular dehydration
2. NADPH2 deficiency and inhibition of fatty acid synthesis
3. Glycosylation of proteins in the crystalline lens and accumulation of sorbitol
4. Decreased oxygen affinity of the proteins
5. Disturbed insulin-receptor binding