Anaprilin (propranoloD. therapy had a positive effect on the disease course in a 44-year-old woman with angina pectoris. What is the mechanism of action of this drug?

Answer options

1. Beta-adrenergic receptor block and a decrease in myocardial oxygen demand
2. Increased oxygen supply to the myocardium
3. Reduction of oxidative metabolism in Krebs cycle enzymes
4. Reduction of myocardial energy consumption due to reduced load
5. Dccrcascd myocardial oxygen demand and increased oxygen supply to the myocardium