A person was hospitalized with morphine poisoning. A specific antagonist, naloxone, is used in acute morphine poisoning. What is the main factor in the development of antagonistic action in such cases?

Answer options

1. Direct stimulation of respiratory metabolism
2. Competition for binding to opioid receptors
3. Strong acceleration of morphine
4. Decreased sensitivity of the body to morphine
5. Reflex excitation of the respiratory center